Wednesday, October 21, 2009

THE KENNEL Club has said it is ‘minded’ to accept registration of my NUA girls from the USA ! Although the breed clubs will be consulted, their views will be sought only on health and welfare aspects of registering the dogs. So what is in the best interests of the health & welfare of Dalmatians could it be to be FREE from a defective gene?
The frequency and severity of urate stone disease, at least in the US there has been enough published research (Dr. Bartges included) to accurately state that approximately 30% of all male Dalmatians (15% of the total Dalmatian population) will have a urate stone episode severe enough to require medical intervention during their lifetime. This is not only extremely painful to the dog, but at times devastatingly costly to the owners.Listen to an interview ....
In order to correct the health problem's associated with High Uric Acid.
The Dalmatian is the ONLY breed of dog with 2 copies of the mutant gene
for HUA - (uu) (see below) fixed into ALL Dalmatians (so you cannot breed away from it with in the lines we have).
The girls pictured below are originated from Dr Bob Schaible
Backcross project, started over 35 years ago. using a single Ch pointer
now 14 generations away! You will note that Dr. Robert Schaible, is a medical
geneticist then at the University of Indiana, this gave us the NORMAL gene
(U) so you will see that both GiGi & Sally have 1 copy of the normal gene.
We will DNA test all their offspring to enable us to continue to incorporate
the U gene into future breedings! In the US 'some' breeders still use unilateral & blue eyes in their breeding, however the NUA program as
NEVER used either of these dogs, so better hearing stats may be expected over most other US Dals!

Tuesday, October 20, 2009

Genotype + Enviroment > Phenotype

In Mendelian genetics, a gene is considered either dominant or recessive, which controls its expression. A dominant gene will be expressed and its corresponding trait will be exhibited, even if it is paired with a recessive gene. A recessive gene will only be visible when paired with another recessive gene.Low uric acid (LUA) is the dominant gene and is typically referred to as normal uric acid for all canine breeds except the Dalmatian.High uric acid (HUA) is the recessive gene and is the major contributing factor in Dalmatian Stone Disease. All Dalmatians have high uric acid except the LUA descendants.When breeding a homozygous LUA Dalmatian (UU) to a homozygous HUA Dalmatian (uu), all progeny will be LUA (Uu). When breeding a heterozygous LUA Dalmatian (Uu) to a HUA Dalmatian (uu), theoretically 50% of the progeny will be LUA (Uu) and 50% will be HUA (uu).When breeding a heterozygous LUA Dalmatian (Uu) to a homozygous LUA Dalmatian (UU), all progeny will be LUA, with theoretically 50% of the progeny being homozygous LUA (UU) and 50% being heterozygous LUA (Uu).When breeding a HUA Dalmatian (uu) to a HUA Dalmatian (uu), 100% of the progeny will be HUA (uu).The results shown are, of course, averages over time, and predictions of what one can expect.

Monday, October 19, 2009

Stocklore's Sally Forth

This is Sally pictured at 3 months. She has 1 copy of the NUA gene (Uu)

Sally is a great,great, great grand daughter
of Eng.Ch.Buffrey Jobee. sally was bred by
lesia Wood & Dr. Bob Schaible. Being lovingly
fostered by Michael Heflin in Texas
Until she ready to come to Wales!

Sunday, October 18, 2009

Aberdeen's Goodness Gracious

This is GiGi she also carries 1 copy of the Normal Uric Acid Gene (Uu) Bred by Denise Powell

Hearing +/+ Hips Good.