Tuesday, October 20, 2009

Genotype + Enviroment > Phenotype

In Mendelian genetics, a gene is considered either dominant or recessive, which controls its expression. A dominant gene will be expressed and its corresponding trait will be exhibited, even if it is paired with a recessive gene. A recessive gene will only be visible when paired with another recessive gene.Low uric acid (LUA) is the dominant gene and is typically referred to as normal uric acid for all canine breeds except the Dalmatian.High uric acid (HUA) is the recessive gene and is the major contributing factor in Dalmatian Stone Disease. All Dalmatians have high uric acid except the LUA descendants.When breeding a homozygous LUA Dalmatian (UU) to a homozygous HUA Dalmatian (uu), all progeny will be LUA (Uu). When breeding a heterozygous LUA Dalmatian (Uu) to a HUA Dalmatian (uu), theoretically 50% of the progeny will be LUA (Uu) and 50% will be HUA (uu).When breeding a heterozygous LUA Dalmatian (Uu) to a homozygous LUA Dalmatian (UU), all progeny will be LUA, with theoretically 50% of the progeny being homozygous LUA (UU) and 50% being heterozygous LUA (Uu).When breeding a HUA Dalmatian (uu) to a HUA Dalmatian (uu), 100% of the progeny will be HUA (uu).The results shown are, of course, averages over time, and predictions of what one can expect.

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